Hypochlorous acid (HClO) is an excellent surface disinfectant and classified as nonhazardous but maintaining a steady HClO solution is extremely difficult. This study aimed to mix HClO with various metal nanoparticles (NPs) to improve stability. The efficiency of the prepared solutions against Salmonella Typhimurium, Salmonella Enteritidis, Salmonella Dublin, and Salmonella Infantis was assessed using the culture method in five distinct experimental groups at varying temperatures (4 ??C, 10 ??C, 25 ??C, 40 ??C, and 50 ??C). The type of metal NPs, HClO, and application temperatures utilized in the combined solutions for bacterial decontamination did not result in a significant difference between the investigated Salmonella serogroups (p > 0.05). At 50 ??C, the highest effective antibacterial activity was detected. There was no statistically significant difference across metal NPs effectiveness ratings (p > 0.05). The antibacterial activity was highest in the 200 ppm HClO + 100 nm AgONP application. According to our findings, we propose mixing these metal NPs with HClO. Using these particles in conjunction with HClO may be an innovative and cost-effective strategy for increasing antimicrobial activity and combating antibacterial resistance in Salmonella.