Biochemical and immunological markers of multiple sclerosis

Seven A., Aslan M.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.32, sa.3, ss.112-119, 2007 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 32 Sayı: 3
  • Basım Tarihi: 2007
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.112-119
  • İstanbul Üniversitesi Adresli: Evet

Özet

Multiple sclerosis is the most common neurological disease in young adults characterized by recurrent relapses and/ or progression within the central nervous system. It is a complex disease in which several pathophysiological mechanisms such as axonal/ neuronal damage, demyelination, inflammation, gliosis, remyelination and repair, oxidative stres and excitotoxicity, alteration of the immune system and disruption of blood- brain barrier are involved. Biological markers; reflecting the immunopathological process, indicating responses to therapeutic interventions and optimizing therapy; are needed for the development of process- specific therapies and the prevention of disability.