Biochemical and immunological markers of multiple sclerosis

Seven A., Aslan M.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.32, no.3, pp.112-119, 2007 (SCI-Expanded) identifier

  • Publication Type: Article / Review
  • Volume: 32 Issue: 3
  • Publication Date: 2007
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.112-119
  • Istanbul University Affiliated: Yes

Abstract

Multiple sclerosis is the most common neurological disease in young adults characterized by recurrent relapses and/ or progression within the central nervous system. It is a complex disease in which several pathophysiological mechanisms such as axonal/ neuronal damage, demyelination, inflammation, gliosis, remyelination and repair, oxidative stres and excitotoxicity, alteration of the immune system and disruption of blood- brain barrier are involved. Biological markers; reflecting the immunopathological process, indicating responses to therapeutic interventions and optimizing therapy; are needed for the development of process- specific therapies and the prevention of disability.