Spectrophotometric determination of mexiletine hydrochloride in capsules using bromothymol blue

Aydogmus Z., Cetin S., Tosunoglu S.

TURKISH JOURNAL OF CHEMISTRY, vol.26, no.6, pp.839-842, 2002 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 6
  • Publication Date: 2002
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.839-842
  • Keywords: spectrophotometry, mexiletine hydrochloride, bromothymol blue, ion-pair
  • Istanbul University Affiliated: Yes


A new spectrophotometric method based on the formation of an ion-pair using bromothymol blue as ion-pair complexing reagent was developed for the determination of mexiletine hydrochloride in capsules. The ion-pair formed was highly coloured and easily extracted with dichloromethane. The calibration curve was linear over the concentration range 1.08-10.8 mug.ml(-1) at lambda(max) = 408 nm (r = 0.9999). The results obtained from the developed method were compared statistically with those obtained by the British Pharmacopeia, method.