Interleukin-12 and Protamine Inhibit Angiogenesis and Growth of C6 Rat Glioma: Synergistic Effects and Role of Th2 Cells

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TURNA A., KIRAN B., Ozar E., TURNA Z. H., Mercan C. A., Buyukpinarbasili N., ...More

TURKISH JOURNAL OF IMMUNOLOGY, vol.1, no.3, pp.68-73, 2013 (ESCI)

• Publication Type: Article / Article
• Volume: 1 Issue: 3
• Publication Date: 2013
• Doi Number: 10.5606/tji.2013.268
• Journal Name: TURKISH JOURNAL OF IMMUNOLOGY
• Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
• Page Numbers: pp.68-73
• Keywords: Angiogenesis, C6, glioma, interleukin-12, lymphocyte, protamine, Th1 cell, Th2 cell
• Istanbul University Affiliated: Yes

Abstract

Objectives: This study aims to investigate the anti-tumoral, anti-angiogenic and immunologic effects of interleukin-12 (IL-12) in combination with protamine in intracranially inoculated rat C6 glioma model.