INTERNATIONAL JOURNAL OF DERMATOLOGY, cilt.56, sa.2, ss.166-170, 2017 (SCI-Expanded)
BackgroundInvasion of the lymphatic or vascular vessels by the primary tumor is considered a sign of aggressive disease that leads to metastases to the regional lymph nodes and to distant sites. Although lymphovascular invasion (LVI) is one of the major characteristics of a primary melanoma tumor, its prognostic significance remains controversial.