Effect of acute and chronic administration of sodium valproate on lipid peroxidation and antioxidant system in rat liver.

Seckin S., Basaran-Kucukgergin C., Uysal M.

Pharmacology & toxicology, cilt.85, sa.6, ss.294-8, 1999 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 85 Sayı: 6
  • Basım Tarihi: 1999
  • Doi Numarası: 10.1111/j.1600-0773.1999.tb02025.x
  • Dergi Adı: Pharmacology & toxicology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.294-8
  • İstanbul Üniversitesi Adresli: Evet

Özet

Changes in glutathione and lipid peroxide levels as well as in the activities of superoxide dismutase, glutathione peroxidase, catalase and glutathione-S-transferase have been studied in rats after acute and chronic sodium valproate treatments. Glutathione levels were decreased only after acute sodium valproate treatment. Neither acute nor chronic treatment influenced lipid peroxidation but induced glutathione-S-transferase activity significantly. On the other hand, no alterations in glutathione peroxidase and superoxide dismutase activities were found, except slight induction of catalase activity after acute administration of sodium valproate. These results indicate that sodium valproate treatment did not induce oxidative stress in the liver.