Relapse of hepatitis B in HBeAg-negative chronic hepatitis B patients who discontinued successful entecavir treatment: The case for continuous antiviral therapy

Shouval, Daniel; Lai, Ching-Lung; Chang, Ting-Tsung; Cheinquer, Hugo; Martin, Paul; Carosi, Glamplero; Han, Steven; Kaymakoglu, Sabahattin; Tamez, Ricardo; Yang, Joanna; Tenney, Daniel; Brett-Smith, Helena

doi:10.1016/j.jhep.2008.10.017

Relapse of hepatitis B in HBeAg-negative chronic hepatitis B patients who discontinued successful entecavir treatment: The case for continuous antiviral therapy

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Shouval D., Lai C., Chang T., Cheinquer H., Martin P., Carosi G., ...More

JOURNAL OF HEPATOLOGY, vol.50, no.2, pp.289-295, 2009 (SCI-Expanded)

Publication Type: Article / Article
Volume: 50 Issue: 2
Publication Date: 2009
Doi Number: 10.1016/j.jhep.2008.10.017
Journal Name: JOURNAL OF HEPATOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.289-295
Istanbul University Affiliated: No

Abstract

Background/Aims: To evaluate the off-treatment durability of response in HBeAg-negative chronic hepatitis B patients who achieved a protocol-defined 'Response' (HBV-DNA < 0.7 MEq/mL and ALT < 1.25 x ULN) with entecavir at 48 weeks and the efficacy of entecavir in patients treated beyond one year.