Spectrophotometric determination of glimepiride in pharmaceutical preparations based on the formation of charge-transfer and ion-pair complexes


Ulu S.

JOURNAL OF ANALYTICAL CHEMISTRY, cilt.68, ss.606-610, 2013 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 68 Konu: 7
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1134/s1061934813070101
  • Dergi Adı: JOURNAL OF ANALYTICAL CHEMISTRY
  • Sayfa Sayıları: ss.606-610

Özet

Two rapid, simple, accurate and sensitive spectrophotometric methods were developed for the determination of glimepiride in pharmaceutical preparations. The first method was based on the formation of a charge-transfer complex of the drug, as n-electron donor, with 7,7,8,8-tetracyanoquinodimethane (TCNQ), as pi-acceptor. The second method was based on the formation of ion-pair complexes between the examined drug and bromothymol blue (BTB).