Antibacterial and antibiofilm activities of ceragenins against Achromobacter species isolated from cystic fibrosis patients

Damar-Celik D., Mataraci-Kara E., Savage P. B., Ozbek-Celik B.

Journal of Chemotherapy, cilt.33, sa.4, ss.216-227, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 4
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1080/1120009x.2020.1819702
  • Dergi Adı: Journal of Chemotherapy
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.216-227
  • Anahtar Kelimeler: Achromobacterspecies, antibacterial, biofilm, ceragenins, cystic fibrosis, ACHROMOBACTER-XYLOSOXIDANS, PSEUDOMONAS-AERUGINOSA, CSA-13, BIOFILMS, SUSCEPTIBILITIES, PREVALENCE, F-127
  • İstanbul Üniversitesi Adresli: Evet

Özet

© 2020 Edizioni Scientifi che per l'Informazione su Farmaci e Terapia.Achromobacter species, which are recognized as emerging pathogens isolated from patients with cystic fibrosis, are capable of forming biofilm in the respiratory tract in patients and innate multidrug resistance to antimicrobials. CSAs are cationic salt derivatives that mimic the activity of antimicrobial peptides and exhibit antimicrobial activity against bacteria. In this study, the in vitro activities of various ceragenins against Achromobacter-species biofilms were investigated comparatively with a conventional antibiotic (meropenem). Biofilm-formation inhibition and biofilm-adhesion inhibition were investigated on five strong biofilm-producing strains. The lowest MIC50 result was obtained with CSA-13. All of the tested CSAs showed significant biofilm inhibitory activity in the manner of a time- and concentration-dependent effect. To the best of our knowledge, this is the first article to evaluate the antibacterial and antibiofilm activities of tested CSAs against Achromobacter species.