Synthesis and Antimicrobial Activity of Some Novel Schiff Bases Containing 1,2,4-Triazole-3-thione

Calisir M. M., Koçyiğit-Kaymakçıoğlu B., Ozbek B., Otuk G.

E-JOURNAL OF CHEMISTRY, vol.7, 2010 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 7
  • Publication Date: 2010
  • Doi Number: 10.1155/2010/195725
  • Journal Name: E-JOURNAL OF CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Istanbul University Affiliated: Yes

Abstract

A series of Schiff bases (4a-j) were prepared by reacting 4-amino-5-(1-phenylethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione and substituted aromatic aldehydes. The chemical structures were confirmed by means of UV, (1)H NMR, IR, MS(API-ES) spectral data and elemental analysis. All the synthesized compounds were screened for their antimicrobial activity. Among the tested compounds, Schiff bases with 4-OH and 4-NO(2) substituent exhibited remarkable antimicrobial activity against all the tested microorganism.