Pineal germinoma associated with multiple congenital melanocytic nevi: A unique presentation

Aker F., Berkman Z., Aydingoz I., Hakan T., Toksoy G.

NEUROPATHOLOGY, cilt.25, sa.4, ss.336-340, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 4
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1111/j.1440-1789.2005.00617.x
  • Dergi Adı: NEUROPATHOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.336-340
  • Anahtar Kelimeler: congenital melanocytic nevus, extragonadal germ cell tumors, germinoma, large congenital melanocytic nevi, multiple congenital melanocytic nevi, pineal tumors, GERM-CELL TUMORS, INTRACRANIAL GERMINOMA, PROLIFERATIVE NODULES, DOWNS-SYNDROME, PATHOGENESIS
  • İstanbul Üniversitesi Adresli: Hayır

Özet

Intracranial germ cell tumors are rarely seen and typically localize in the pineal or suprasellar region. The largest category of germ cell tumors is the germinoma. There have been reported associations of malignant tumors and chromosomal abnormalities in germ cell tumors. In this study, we present a 22-year-old man with multiple congenital melanocytic nevi in association with pineal tumor. Congenital melanocytic lesions greater than 2 cm were counted to be 54 in number, and those smaller than 1 cm in diameter were found to be 25 in number. The pathological diagnosis of the pineal tumors was germinoma, and the lesions located in the occipital region and trunk were compound congenital nevi. To our knowledge, a relationship between multiple congenital melanocytic nevi and germ cell tumors has not been reported before. The connection between them remains to be clarified.