The effects of systemic and intratumoral interleukin-12 treatment in C6 rat glioma model
NEUROLOGICAL RESEARCH, vol.30, no.5, pp.511-517, 2008 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 30 Issue: 5
- Publication Date: 2008
- Doi Number: 10.1179/174313208x289516
- Journal Name: NEUROLOGICAL RESEARCH
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.511-517
- Istanbul University Affiliated: Yes
Abstract
Objective: Cytokine based immunotherapy has long been an exciting field for many investigators aiming to provide an effective alternative treatment modality for glioma management. Among these cytokines, interleukin-12 (IL-12) plays a crucial role in mediating inflammatory and antitumoral activity on the host defence. We have investigated the therapeutic role of systemic and local delivery of IL-12 in C6 rat glioma model and compared these two modalities.