Association of the Uncoupling Protein 2-866 G/A Polymorphism with Family History and Duration of Tobacco Use Disorder in a Turkish Population

Aytac H. M., Pehlivan S., Kurnaz S., PEHLİVAN M., Aydin P. C.

PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY, vol.31, no.3, pp.280-285, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.5152/pcp.2021.21526
  • Journal Name: PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.280-285
  • Keywords: Nicotine, single nucleotide polymorphism, tobacco use disorder, uncoupling protein 2, UCP2-866 G/A, MITOCHONDRIAL, VARIANTS, GENES
  • Istanbul University Affiliated: Yes

Abstract

Background: A variety of substances cause neurotoxicity by increasing intracellular oxidative stress, followed by mitochondrial dysfunction. Uncoupling proteins (UCPs) act as membrane transport proteins and reduce reactive oxygen products and mitochondrial calcium influx. We aimed to study UCP2-866 G/A gene polymorphism in tobacco use disorder (TUD) by comparing genotype distributions between TUD patients and healthy controls considering clinical parameters.