Synthesis, characterization and antimicrobial activity of 2-(5-H/Me/F/Cl/NO2-1H-benzimidazol-2-yl)-benzene-1,4-diols and some transition metal complexes

Tavman A., Cinarli A., Gurbuz D., Birteksoz A. S.

JOURNAL OF THE IRANIAN CHEMICAL SOCIETY, vol.9, no.5, pp.815-825, 2012 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 5
  • Publication Date: 2012
  • Doi Number: 10.1007/s13738-012-0098-z
  • Journal Name: JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.815-825
  • Keywords: Benzimidazole, Benzene-1,4-diols, Metal complexes, Antimicrobial activity, Fluorescence spectroscopy, INTRAMOLECULAR PROTON-TRANSFER, STATIC LIGHT-SCATTERING, SPECTRAL CHARACTERIZATION, IRON(III) COMPLEXES, TRANSFER MECHANISM, SPECTROSCOPIC CHARACTERIZATION, STRUCTURAL-CHARACTERIZATION, FLUORESCENT MONOMERS, ZINC(II) COMPLEXES, AB-INITIO
  • Istanbul University Affiliated: Yes

Abstract

2-(5-H/Me/F/Cl/NO2-1H-benzimidazol-2-yl)-benzene-1,4-diols (HL (X) : X = 1-5) and HL1 complexes with Fe(NO3)(3), Co(NO3)(2), Ni(NO3)(2), Cu(NO3)(2), Zn(NO3)(2) salts have been synthesized and characterized. The structures of the complexes were confirmed on the basis of elemental analysis, TGA, molar conductivity and magnetic moment measurements, FT-IR, NMR, mass, UV-visible and fluorescence spectroscopy. Metal:ligand ratio for the Ni(II) complex is 1:2, whereas 1:1 for the others. Antibacterial activity of the compounds was evaluated against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Proteus mirabilis. Antifungal activities were reported for Candida albicans. All of the complexes have higher antifungal effect than the ligand, and Zn(II) complex is effective toward especially S. aureus and S. epidermidis (Gram+ bacteria) that the ligand has lower effect on them.