Biodegradable microspherical implants containing teicoplanin for the treatment of methicillin-resistant Staphylococcus aureus osteomyelitis

Orhan, Zafer; Cevher, ERDAL; Yildiz, AYCA; Ahiskali, Rengin; Sensoy, Demet; Muelazimoglu, Luetfiye

doi:10.1007/s00402-009-0886-9

Biodegradable microspherical implants containing teicoplanin for the treatment of methicillin-resistant Staphylococcus aureus osteomyelitis

Orhan Z., Cevher E., Yildiz A., Ahiskali R., Sensoy D., Muelazimoglu L.

ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY, cilt.130, sa.1, ss.135-142, 2010 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 130 Sayı: 1
Basım Tarihi: 2010
Doi Numarası: 10.1007/s00402-009-0886-9
Dergi Adı: ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.135-142
Anahtar Kelimeler: TCP-PLGA implants, Osteomyelitis, MRSA, PHARMACOKINETIC PROPERTIES, DELIVERY-SYSTEM, BONE-INFECTIONS, VIVO EVALUATION, IN-VITRO, CIPROFLOXACIN, THERAPY, RELEASE, MODEL, BEADS
İstanbul Üniversitesi Adresli: Evet

Özet

The aim of this study was to prepare poly(d,l-lactide-co-glycolide) (PLGA) microspherical implants containing teicoplanin (TCP) using a double emulsion solvent evaporation method and to evaluate its efficacy for the local treatment of chronic osteomyelitis.