Association of a syndrome resembling Wegener's granulomatosis with low surface expression of HLA class-I molecules

Moins-Teisserenc, HT; Gadola, SD; Cella, M; Dunbar, PR; Exley, A; Blake, N; Baykal, Can; Lambert, J; Bigliardi, P; Willemsen, M; Jones, M; Buechner, S; Colonna, M; Gross, WL; Cerundolo, V

doi:10.1016/s0140-6736(99)04206-3

Association of a syndrome resembling Wegener's granulomatosis with low surface expression of HLA class-I molecules

Moins-Teisserenc H., Gadola S., Cella M., Dunbar P., Exley A., Blake N., ...Daha Fazla

LANCET, cilt.354, sa.9190, ss.1598-1603, 1999 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 354 Sayı: 9190
Basım Tarihi: 1999
Doi Numarası: 10.1016/s0140-6736(99)04206-3
Dergi Adı: LANCET
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1598-1603
İstanbul Üniversitesi Adresli: Evet

Özet

Background Granulomatous syndromes, such as Wegener's granulomatosis, are defined according to complex criteria, but the underlying cause is rarely identified. We present evidence for a new aetiology for chronic granulomatous lesions associated with a recessive genetic defect, which is linked to the human leucocyte antigen (HLA) locus.