Association of a syndrome resembling Wegener's granulomatosis with low surface expression of HLA class-I molecules

Moins-Teisserenc H., Gadola S., Cella M., Dunbar P., Exley A., Blake N., ...Daha Fazla

LANCET, cilt.354, sa.9190, ss.1598-1603, 1999 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 354 Sayı: 9190
  • Basım Tarihi: 1999
  • Doi Numarası: 10.1016/s0140-6736(99)04206-3
  • Dergi Adı: LANCET
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1598-1603
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background Granulomatous syndromes, such as Wegener's granulomatosis, are defined according to complex criteria, but the underlying cause is rarely identified. We present evidence for a new aetiology for chronic granulomatous lesions associated with a recessive genetic defect, which is linked to the human leucocyte antigen (HLA) locus.