Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia

Pardinas A. F., Smart S. E., Willcocks I. R., Holmans P. A., Dennison C. A., Lynham A. J., ...Daha Fazla

JAMA PSYCHIATRY, cilt.79, sa.3, ss.260-269, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 79 Sayı: 3
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1001/jamapsychiatry.2021.3799
  • Dergi Adı: JAMA PSYCHIATRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, BIOSIS, CINAHL, EMBASE, MEDLINE, Psycinfo
  • Sayfa Sayıları: ss.260-269
  • İstanbul Üniversitesi Adresli: Hayır

Özet

IMPORTANCE About 20% to 30% of people with schizophrenia have psychotic symptoms that do not respond adequately to first-line antipsychotic treatment. This clinical presentation, chronic and highly disabling, is known as treatment-resistant schizophrenia (TRS). The causes of treatment resistance and their relationships with causes underlying schizophrenia are largely unknown. Adequately powered genetic studies of TRS are scarce because of the difficulty in collecting data from well-characterized TRS cohorts.