The molecular markers of hemostatic activation on coronary artery disease

Ulutin T., Sonmez H. A., Ucisik N., Suer S., Bayram C., Kokoglu E. H., ...Daha Fazla

THROMBOSIS RESEARCH, cilt.88, sa.3, ss.329-332, 1997 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 88 Sayı: 3
  • Basım Tarihi: 1997
  • Doi Numarası: 10.1016/s0049-3848(97)00262-4
  • Dergi Adı: THROMBOSIS RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.329-332
  • İstanbul Üniversitesi Adresli: Evet

Özet

Endothelial cells, circulating platelets, and proteins of the coagulation and fibrinolytic systems are known to contribute to the hemostatic processes. Various molecular markers of hemostatic alteration are found in increased amounts in the circulation during the activation of this process. In this study, we investigated serum lipoprotein (a) and plasma platelet factor 4, beta-thromboglobulin, thrombin-anthithrombin complex, fibrinopeptid A, D-dimer, tissue plasminogen activator, tissue plasminogen activator inhibitor, and fibronectin levels in patients with coronary artery disease. The levels of all these markers were found to be significantly higher as compared to the control group. Our findings suggest that patients with coronary artery disease have greater blood coagulability than controls, and the use of molecular markers has become greatly important in clinical practice. (C) 1998 Elsevier Science Ltd.