Akademik Veri Yönetim Sistemi
18th Congress of the International Union of Microbiological Societies (IUMS), Florence, İtalya, 23 - 25 Ekim 2024, ss.55, (Özet Bildiri)
Backgrounds: The
skin, which is the physical barrier of the immune system with its low pH and
the presence of sweat glands, creates a suitable environment for colonization
of microorganisms. Skin infections caused by fungi, which are eukaryotic microorganisms,
are called dermatophytes. It is known that fungi can develop resistance due to
environmental stress such as biofilm formation, target mismatch, drug transport
systems and cell permeability. Cosmetic products which are applied externally
to the skin, also likely to create environmental stress. There are many types of cosmetic
products on the market, in moisturizing, protective and care-giving forms.
Objectives: In
this study, we determined the antifungal and anti-biofilm effectiveness of some
raw materials that are frequently encountered in formulation of cosmetics against
clinical dermatophyte isolates.
Methods: The biofilm forming capacities of the isolates were determined by crystal
violet staining method. The minimum inhibitory concentrations (MIC) and
minimum biofilm eradication concentrations (MBEC) of raw materials were determined by
microbroth dilution technique.
Results: While three Microsporium canis and two Trichopyton rubrum isolates were strong, T. tonsurans was weak biofilm positive. Among the cosmetic raw materials gliserin, UV filter octocrylene, tea tree oil, vitamin A, panthenol, cantella, UV filter benzo, and UV filter diethy have antifungal activities between 0.002-0.25 µg/ml concentrations. Also these materials were intibit the mature biofilms up to 3-log10 cfu/ml. According to these results, cosmetic raw materials have the antifungal and antibiofilm potential for treatment of dermatophytes.