Atypical M-protein localization in protein electrophoresis in a patient with multiple myeloma

Yildirim N. D., Ayer M., Hatipoglu E., Kucukkaya R. D., Yenerel M. N., Nalcaci M.

TRAKYA UNIVERSITESI TIP FAKULTESI DERGISI, cilt.25, sa.1, ss.56-59, 2008 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 1
  • Basım Tarihi: 2008
  • Dergi Adı: TRAKYA UNIVERSITESI TIP FAKULTESI DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.56-59
  • Anahtar Kelimeler: blood protein electrophoresis, multiple myeloma, paraproteinemias
  • İstanbul Üniversitesi Adresli: Evet

Özet

Monoclonal gammopathy is a group of B-cell disorders resulting in the secretion of a specific and unique monoclonal immunoglobulin (M-component). The best method for detecting a monoclonal protein is high resolution agarose gel electrophoresis. This test detects abnormalities in the migration of the proteins on electrophoresis and can be performed with samples of serum or urine. An M-protein is usually visible as a localized band on agarose gel electrophoretic peak in the beta, gamma, or rarely in the alpha-2 globulin region of the densitometer tracing. Here, we presented a multiple myeloma patient with IgA kappa paraprotein showing an M spike in the alpha-2 globulin region in agarose gel electrophoresis.