HLA-DRB1*15 and pediatric aplastic anemia

Oguz F., Yalman N., Diler A., Oguz R., Anak S., Dorak M.

HAEMATOLOGICA, cilt.87, sa.7, ss.772-774, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Kısa Makale
  • Cilt numarası: 87 Sayı: 7
  • Basım Tarihi: 2002
  • Dergi Adı: HAEMATOLOGICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.772-774
  • Anahtar Kelimeler: HLA-DRB1, aplastic anemia, immunogenetics, genetic predisposition, IMMUNOSUPPRESSIVE THERAPY, FREQUENCY
  • İstanbul Üniversitesi Adresli: Evet

Özet

We report a positive association between HLA-DRB1*15 (p = 0.0002) in Turkish patients with pediatric severe aplastic anemia (SAA) and a paradoxically favorable influence of the susceptibility marker on the clinical response to immunosuppressive therapy. These findings point to an immune mechanism mediated by DRB1*15 in SAA which confers responsiveness to treatment.