Analysis of L-MYC gene polymorphism in patients with renal failure outcome to renal transplant

Yiğit B., Bozkurt N., Yaylim I., Titiz İ., İşbir T.

TRANSPLANTATION PROCEEDINGS, cilt.38, sa.5, ss.1267-1269, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 5
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.transproceed.2006.03.037
  • Dergi Adı: TRANSPLANTATION PROCEEDINGS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1267-1269
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background. Abnormalities of cell numbers and apoptosis have been observed in renal failure. As uncontrolled expression of c-myc is known to induce apoptosis, we thought that polymorphism in the other myc gene, L-myc gene, which is structually similar to c-myc and reported to be expressed in the kidney, may have a role in the induction of apoptosis and thus have role in chronic renal failure. The aim of this study was to investigate the relationship between the distribution of L-myc genotypes and renal failure.