Recombination frequencies of human leukocyte antigen loci in hematological malignancies among Turkish population.

ÇINAR Ç., TEMURHAN S., ÖGRET Y., Akgul S. U., Hayriye Senturk C., BEŞIŞIK S., ...Daha Fazla

International journal of laboratory hematology, cilt.43, sa.6, ss.1432-1436, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 6
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1111/ijlh.13613
  • Dergi Adı: International journal of laboratory hematology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1432-1436
  • Anahtar Kelimeler: cross over, hematological malignancies, human leukocyte antigen, locus, recombination
  • İstanbul Üniversitesi Adresli: Evet

Özet

Introduction Allogeneic hematopoietic stem cell transplantation (HSCT) is a treatment option with growing performance for leukaemia, aplastic anaemia and genetic disorders. The frequency of MHC (Major Histocompatibility Complex) gene locus recombination is increased at loci close to the telomeres and in the female gender. The aim of the present study is to document the recombination events by pedigree diagrams with the primary goal to determine the frequency of recombination in a different ethnic population from mostly reported studies.