Pulmonary Valve Amyloid Deposition Mimicking Infective Endocarditis in Val30Met Hereditary Transthyretin Amyloidosis
Echocardiography, cilt.43, sa.10, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 43 Sayı: 10
- Basım Tarihi: 2026
- Doi Numarası: 10.1111/echo.70651
- Dergi Adı: Echocardiography
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE, Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO)
- Anahtar Kelimeler: cardiac mass, echocardiography, hereditary transthyretin amyloidosis, pulmonary valve
- İstanbul Üniversitesi Adresli: Evet
Özet
A 53-year-old man with Val30Met hereditary transthyretin amyloidosis (hATTR) developed a highly mobile pulmonary valve mass with severe pulmonary regurgitation. Concomitant methicillin-sensitive Staphylococcus aureus (MSSA) bacteremia raised suspicion for infective endocarditis. Echocardiography and cardiac magnetic resonance imaging characterized the lesion but could not establish its etiology. Surgical excision and pulmonary valve replacement were performed, and histopathological examination demonstrated Congo red–positive amyloid deposition. This case highligts that atypical cardiac manifestations beyond myocardial infiltration can occur in patients with hATTR. We present a case of isolated pulmonary valvular amyloid infiltration without overt myocardial involvement in Val30Met-associated hATTR.