Human genome and diseases: Review immunology and functional genomics of Behcet's disease

Zierhut M., Mizuki N., Ohno S., Inoko H., Gul A., Onoe K., ...More

CELLULAR AND MOLECULAR LIFE SCIENCES, vol.60, no.9, pp.1903-1922, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 60 Issue: 9
  • Publication Date: 2003
  • Doi Number: 10.1007/s00018-003-2333-3
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1903-1922
  • Keywords: Behcet's disease, vasculitis, uveitis, experimental autoimmume uveitis, HLA, streptococcus, herpes simplex virus, heat shock protein, T cells, NK-T-cells, neutrophils, cytokines, endothelial dysfunction, coagulation and fibrinolytic pathway abnormalities, HEAT-SHOCK-PROTEIN, HLA CLASS-I, T-CELL SUBSETS, EXPERIMENTAL AUTOIMMUNE UVEORETINITIS, MAJOR HISTOCOMPATIBILITY COMPLEX, MIGRATION-INHIBITORY FACTOR, NATURAL-KILLER-CELLS, FACTOR-V-LEIDEN, RECEPTOR ALPHA/BETA(+) THYMOCYTES, NITRIC-OXIDE PRODUCTION
  • Istanbul University Affiliated: Yes


Behcet's disease (BD) is a multisystemic inflammatory disorder. Although the cause and pathogenesis of BD are still unclear, there is evidence for genetic, immunologic and infectious factors at the onset or in the course of BD. This review focusses on the functional genomics and immunology of BD. HLA-B51 is the major disease susceptibility gene locus in BD. An increased number of gammadeltaT cells in the peripheral blood and in the involved tissues have been reported. However, the T cells at the sites of inflammation appear to be a phenotypically distinct subset. There is also a significant gammadelta T cell proliferative response to mycobacterial 65-kDa heat shock protein peptides. Homologous peptides derived from the human 60-kDa heat shock protein were observed in BD patients. There is evidence that natural killer T cells may also play a role in BD.