Detecting Amyloid Goiter With <SUP>99m</SUP>Tc-PYP SPECT/CT in the Setting of Ankylosing Spondylitis: An Uncommon Involvement of AA Amyloidosis

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Denizmen D., Salmaslioglu A., Bakkaloglu D., Simsek D. H., Sanli Y.

CLINICAL NUCLEAR MEDICINE, vol.49, no.8, 2024 (SCI-Expanded, Scopus)

• Publication Type: Article / Editorial Material
• Volume: 49 Issue: 8
• Publication Date: 2024
• Doi Number: 10.1097/rlu.0000000000005280
• Journal Name: CLINICAL NUCLEAR MEDICINE
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
• Keywords: 99mTc-PYP scintigraphy, AA amyloidosis, amyloid goiter, ankylosing spondylitis
• Istanbul University Affiliated: Yes

Abstract

We present a case with systemic amyloidosis secondary to ankylosing spondylitis (AA amyloidosis), whose Tc-99m PYP scintigraphy revealed amyloid deposition in the thyroid gland (amyloid goiter). Amyloidosis is characterized by extracellular accumulation of amyloid fibril proteins leading to organ malfunction. Even though AA amyloidosis can be observed in patients with systemic inflammatory diseases, it is a very rare complication in ankylosing spondylitis. SPECT/CT images showed diffuse tracer uptake in enlarged thyroid gland containing fat density areas.