UCP2 and CFH Gene Variants with Genetic Susceptibility to Schizophre-nia in Turkish Population


NURSAL A. F., Aydin P. C., PEHLİVAN M., Sever U., Pehlivan S.

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS, vol.21, no.11, pp.2084-2089, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 11
  • Publication Date: 2021
  • Doi Number: 10.2174/1871530320999201113103730
  • Journal Name: ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.2084-2089
  • Keywords: Schizophrenia, uncoupling protein 2, complement factor H, variant, Turkish population, genome-wide association Studies, COMPLEMENT FACTOR-H, UNCOUPLING PROTEIN-2 UCP2, MACULAR DEGENERATION, POLYMORPHISM, CYTOKINES, IMMUNITY, OBESITY, RISK, AUTOIMMUNITY, ASSOCIATION
  • Istanbul University Affiliated: Yes

Abstract

Objective: Schizophrenia (Sch) is a complex, multifactorial psychiatric disorder. Growing evidence shows that oxidative damage and immunological dysfunction exist in the Sch physiopathology. In the present study, we aimed to evaluate whether the Uncoupling protein 2 and Complement factor H gene variants play any role in susceptibility to Sch. Methods: This study was carried out on 200 individuals (100 Sch patients and 100 healthy controls). Genomic DNA was extracted from blood samples. UCP2-866G /A (rs659366) and CFHY402H variants were analyzed by PCR-RFLP analysis. Results: The UCP2-866G/A variant G/G genotype and G allele were associated significantly with increased risk of Sch (p=0.001, p=0.001, respectively). The subjects were carrying UCP2-866G/A variant G/G genotype had 4.377-fold increased risk for Sch. There was no significant difference between the groups for the genotype and allele frequencies of the CFH Y402H variant (p>0.05). The observed genotype counts deviated significantly from those expected in Sch patients according to the HWE for UCP2-866G/A variant (p=0.001). Conclusion: We present the first results investigating UCP2-866G/A/ and CFH Y402H variants for susceptibility to Sch in a Turkish population. These results indicate that the UCP2 -866G/A, but not CFHY402H variant, might play an important role in the development of Sch.