Cytosolic 5 '-nucleotidase III (NT5C3): gene sequence variation and functional genomics

Aksoy P., Zhu M. J., Kalari K. R., Moon I., Pelleymounter L. L., Eckloff B. W., ...Daha Fazla

PHARMACOGENETICS AND GENOMICS, cilt.19, sa.8, ss.567-576, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 8
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1097/fpc.0b013e32832c14b8
  • Dergi Adı: PHARMACOGENETICS AND GENOMICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.567-576
  • İstanbul Üniversitesi Adresli: Hayır

Özet

Background 5'-Nucleotidases play a critical role in nucleotide pool balance and in the metabolism of nucleoside analogs such as gemcitabine and cytosine arabinoside (AraC). We previously performed an expression array association study with gemcitabine and AraC cytotoxicity using 197 human lymphoblastoid cell lines. One gene that was significantly associated with gemcitabine cytotoxicity was a nucleotidase family member, NT5C3. Very little is known with regard to the pharmacogenomics of this family of enzymes.