Effects of levetiracetam on blood-brain barrier disturbances following hyperthermia-induced seizures in rats with cortical dysplasia

Ahishali B., Kaya M., Orhan N., Arican N., Ekizoglu O., Elmas I., ...Daha Fazla

LIFE SCIENCES, cilt.87, ss.609-619, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 87
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.lfs.2010.09.014
  • Dergi Adı: LIFE SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.609-619
  • Anahtar Kelimeler: Levetiracetam, Blood-brain barrier, Seizures, TUBEROUS SCLEROSIS COMPLEX, INDUCED STATUS EPILEPTICUS, TEMPORAL-LOBE EPILEPSY, ANTIEPILEPTIC DRUG, FEBRILE SEIZURES, KINDLED RATS, INTRAVENOUS LEVETIRACETAM, UCB L059, MODEL, PROTEIN
  • İstanbul Üniversitesi Adresli: Evet

Özet

Aims: The mechanisms underlying the changes in blood-brain barrier (BBB) integrity and the generation of seizures in childhood associated with preexisting brain lesions like cortical dysplasia (CD) are poorly understood. We investigated the effects of levetiracetam (LEV) on BBB integrity and the survival during hyperthermic seizures in rats with CD.