Effects of levetiracetam on blood-brain barrier disturbances following hyperthermia-induced seizures in rats with cortical dysplasia


Ahishali B., Kaya M., Orhan N., Arican N., Ekizoglu O., Elmas I., ...More

LIFE SCIENCES, vol.87, pp.609-619, 2010 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 87
  • Publication Date: 2010
  • Doi Number: 10.1016/j.lfs.2010.09.014
  • Journal Name: LIFE SCIENCES
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.609-619
  • Keywords: Levetiracetam, Blood-brain barrier, Seizures, TUBEROUS SCLEROSIS COMPLEX, INDUCED STATUS EPILEPTICUS, TEMPORAL-LOBE EPILEPSY, ANTIEPILEPTIC DRUG, FEBRILE SEIZURES, KINDLED RATS, INTRAVENOUS LEVETIRACETAM, UCB L059, MODEL, PROTEIN

Abstract

Aims: The mechanisms underlying the changes in blood-brain barrier (BBB) integrity and the generation of seizures in childhood associated with preexisting brain lesions like cortical dysplasia (CD) are poorly understood. We investigated the effects of levetiracetam (LEV) on BBB integrity and the survival during hyperthermic seizures in rats with CD.