Comparison of silver sulfadiazine 1%, mupirocin 2%, and fusidic acid 2% for topical antibacterial effect in methicillin-resistant staphylococci-infected, full-skin thickness rat burn wounds

Acikel, C; Oncul, Mustafa; Ulkur, E; Bayram, I; Celikoz, B; Cavuslu, S

doi:10.1097/00004630-200301000-00008

Comparison of silver sulfadiazine 1%, mupirocin 2%, and fusidic acid 2% for topical antibacterial effect in methicillin-resistant staphylococci-infected, full-skin thickness rat burn wounds

Atıf İçin Kopyala

Acikel C., Oncul O., Ulkur E., Bayram I., Celikoz B., Cavuslu S.

JOURNAL OF BURN CARE & REHABILITATION, cilt.24, sa.1, ss.37-41, 2003 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 24 Sayı: 1
Basım Tarihi: 2003
Doi Numarası: 10.1097/00004630-200301000-00008
Dergi Adı: JOURNAL OF BURN CARE & REHABILITATION
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.37-41
İstanbul Üniversitesi Adresli: Evet

Özet

Silver sulfadiazine 1%, mupirocin 2%, and fusidic acid 2% were compared to assess the antibacterial effect of a once-daily application on experimental rat 15% full-skin thickness burn wounds seeded 24 hours earlier with a 10(8) standard strain of methicillin-resistant staphylococci. The quantitative counts of seeded organism in burn eschar and subjacent muscle were determined at postburn day 7, beside the cultures of blood and lung biopsies. All tested topical agents were equally effective against methicillin- resistant Staphylococcus aureus in reducing local burn wound bacterial count and preventing systemic infection.