Akademik Veri Yönetim Sistemi
Sabiad , cilt.6, sa.2, ss.117-121, 2023 (Hakemli Dergi)
Objective: The purpose of this investigative research was to investigate the potential impact of a single nucleotide polymorphism (Asp148Glu) within the APE1 gene on the development of bladder cancer (BCa) and spread, and to investigate the interaction of this polymorphism with cigarette smoking in BCa patients. Materials and Methods: In a study of 256 participants, consisting of 136 healthy individuals and 120 patients with BCa, the APE1 Asp148Glu polymorphism was evaluated using “polymerase chain reaction restriction- fragment length polymorphism” analysis. Results: There were no noteworthy difference variations observed in genotype distribution between the group of individuals with BCa and the control group with regards to the APE1 gene polymorphism. Furthermore, the APE1 gene polymorphism exhibited no correlation with the clinicopathological characteristics or smoking habits of individuals with BCa. Conclusion: Based on our findings, it appears that the APE1 gene polymorphism, which plays a role in the BER pathway, does not appear to be a contributing factor in susceptibility to BCa in the Turkish population. In addition, the smoking habit may not modify BCa risk with respect to genetic variations in the APE1 gene.