In Vitro Effects of Eicosapentaenoic and Docosahexaenoic Acid on the Vascular Tone of a Human Saphenous Vein: Influence of Precontractile Agents


Daci A., Ozen G. , Karaman E., Teskin O., Caglayan M., Celik Z. , ...Daha Fazla

ANNALS OF VASCULAR SURGERY, cilt.64, ss.318-327, 2020 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 64
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.avsg.2019.09.024
  • Dergi Adı: ANNALS OF VASCULAR SURGERY
  • Sayfa Sayıları: ss.318-327

Özet

Background: Cardiovascular effects of omega-3 polyunsaturated fatty acids including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been widely reported. However, there are limited studies concerning their effects on human blood vessels. Therefore, the aim of this study was to investigate the direct vascular effects of EPA and DHA on the human saphenous vein (SV) precontracted with either prostaglandin F2 alpha (PGF2 alpha), or thromboxane A2 analogue (U46619), or norepinephrine (NE). Moreover, we aimed to investigate the protein expression of free fatty acid receptor 4 (FFAR4) in human SV.