In Vitro Effects of Eicosapentaenoic and Docosahexaenoic Acid on the Vascular Tone of a Human Saphenous Vein: Influence of Precontractile Agents

Daci A., Ozen G., Karaman E., Teskin O., Caglayan M., Celik Z., ...More

ANNALS OF VASCULAR SURGERY, vol.64, pp.318-327, 2020 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 64
  • Publication Date: 2020
  • Doi Number: 10.1016/j.avsg.2019.09.024
  • Journal Name: ANNALS OF VASCULAR SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Page Numbers: pp.318-327
  • Istanbul University Affiliated: Yes

Abstract

Background: Cardiovascular effects of omega-3 polyunsaturated fatty acids including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been widely reported. However, there are limited studies concerning their effects on human blood vessels. Therefore, the aim of this study was to investigate the direct vascular effects of EPA and DHA on the human saphenous vein (SV) precontracted with either prostaglandin F2 alpha (PGF2 alpha), or thromboxane A2 analogue (U46619), or norepinephrine (NE). Moreover, we aimed to investigate the protein expression of free fatty acid receptor 4 (FFAR4) in human SV.