Losartan may prevent the elevation of plasma glucose levels induced by chronic stress


Uresin Y. , Erbas B., Ozek M.

POLISH JOURNAL OF PHARMACOLOGY, cilt.56, ss.271-273, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 56 Konu: 2
  • Basım Tarihi: 2004
  • Doi Numarası: 10.3317/jraas.2004.017
  • Dergi Adı: POLISH JOURNAL OF PHARMACOLOGY
  • Sayfa Sayıları: ss.271-273

Özet

The effect of angiotensin II antagonist, losartan, on chronic stress-induced elevation of blood glucose levels was investigated in rats. Chronic immobilization stress caused an increase in blood glucose levels in rats. Administration of losartan (3 mg/kg, po) before stress exposure significantly prevented this increment. We suggest that losartan showed this effect by decreasing the excessive sympathetic response to stress. In conclusion, there is a relationship between stress, sympathetic nervous system, and reninangiotensin system.