Losartan may prevent the elevation of plasma glucose levels induced by chronic stress
POLISH JOURNAL OF PHARMACOLOGY, cilt.56, sa.2, ss.271-273, 2004 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 56 Sayı: 2
- Basım Tarihi: 2004
- Doi Numarası: 10.3317/jraas.2004.017
- Dergi Adı: POLISH JOURNAL OF PHARMACOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.271-273
- İstanbul Üniversitesi Adresli: Evet
Özet
The effect of angiotensin II antagonist, losartan, on chronic stress-induced elevation of blood glucose levels was investigated in rats. Chronic immobilization stress caused an increase in blood glucose levels in rats. Administration of losartan (3 mg/kg, po) before stress exposure significantly prevented this increment. We suggest that losartan showed this effect by decreasing the excessive sympathetic response to stress. In conclusion, there is a relationship between stress, sympathetic nervous system, and reninangiotensin system.