Losartan may prevent the elevation of plasma glucose levels induced by chronic stress
POLISH JOURNAL OF PHARMACOLOGY, vol.56, no.2, pp.271-273, 2004 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 56 Issue: 2
- Publication Date: 2004
- Doi Number: 10.3317/jraas.2004.017
- Journal Name: POLISH JOURNAL OF PHARMACOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.271-273
- Istanbul University Affiliated: Yes
Abstract
The effect of angiotensin II antagonist, losartan, on chronic stress-induced elevation of blood glucose levels was investigated in rats. Chronic immobilization stress caused an increase in blood glucose levels in rats. Administration of losartan (3 mg/kg, po) before stress exposure significantly prevented this increment. We suggest that losartan showed this effect by decreasing the excessive sympathetic response to stress. In conclusion, there is a relationship between stress, sympathetic nervous system, and reninangiotensin system.