Losartan may prevent the elevation of plasma glucose levels induced by chronic stress


Uresin Y. , Erbas B., Ozek M.

POLISH JOURNAL OF PHARMACOLOGY, vol.56, no.2, pp.271-273, 2004 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 56 Issue: 2
  • Publication Date: 2004
  • Doi Number: 10.3317/jraas.2004.017
  • Title of Journal : POLISH JOURNAL OF PHARMACOLOGY
  • Page Numbers: pp.271-273

Abstract

The effect of angiotensin II antagonist, losartan, on chronic stress-induced elevation of blood glucose levels was investigated in rats. Chronic immobilization stress caused an increase in blood glucose levels in rats. Administration of losartan (3 mg/kg, po) before stress exposure significantly prevented this increment. We suggest that losartan showed this effect by decreasing the excessive sympathetic response to stress. In conclusion, there is a relationship between stress, sympathetic nervous system, and reninangiotensin system.