Co-existence of Insulin Dependent Diabetes and Graves' Disease in a Patient with Down Syndrome

KUBAT ÜZÜM A., Torun A. N.

TURKISH JOURNAL OF ENDOCRINOLOGY AND METABOLISM, cilt.14, sa.1, ss.17-19, 2010 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 1
  • Basım Tarihi: 2010
  • Dergi Adı: TURKISH JOURNAL OF ENDOCRINOLOGY AND METABOLISM
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.17-19
  • Anahtar Kelimeler: Down's syndrome, autoimmune thyroiditis, insulin dependent diabetes
  • İstanbul Üniversitesi Adresli: Hayır

Özet

Down's syndrome is the most common genetic disorder. It is well established that there is an increased risk of autoimmune endocrine diseases in Down's syndrome. Defect of a gene located on chromosome 21q22.3 causes autoimmune polyglandular syndrome type 1 and this might be related with susceptibility to autoimmune diseases in patients with Down's syndrome. We reported a 20-year-old male with Down's syndrome who was brought to emergency room by his family and had a diagnose of diabetic ketoacidosis and Graves' disease. Underlying mechanisms in co-existing of autoimmune diseases in Down's syndrome, management of such patients and the importance of making the family to be aware of the symptoms of possible subsequent components of the autoimmune polyglandular syndrome are discussed.