Hyper-IgE syndrome with widespread premalign oral papillomas treated with interferon alpha 2b
ACTA DERMATO-VENEREOLOGICA, vol.85, no.5, pp.433-435, 2005 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 85 Issue: 5
- Publication Date: 2005
- Doi Number: 10.1080/00015550510030041
- Journal Name: ACTA DERMATO-VENEREOLOGICA
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.433-435
- Istanbul University Affiliated: Yes
Abstract
We report a case of a 7-year-old girl with hyperimmunoglobulin-E syndrome presenting with widespread oral papillomas which were tested for human papilloma virus DNA and had shown to be at high/intermediate risk group for malignancy. She had elevated levels of IgE, recurrent sinopulmonary infections, atopic-like dermatitis, peripheral eosinophilia and defective neutrophil chemotaxis. Interferon alfa 2b therapy and chemoprophylaxis with sulfamethoxazole-trimethoprim was given. Although the papillomas partially improved with the treatment, sinopulmonary infections continue to occur.