Hyper-IgE syndrome with widespread premalign oral papillomas treated with interferon alpha 2b

Ozarmagan G. , Yazganoglu K. D. , Agacfidan A.

ACTA DERMATO-VENEREOLOGICA, vol.85, no.5, pp.433-435, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 85 Issue: 5
  • Publication Date: 2005
  • Doi Number: 10.1080/00015550510030041
  • Page Numbers: pp.433-435


We report a case of a 7-year-old girl with hyperimmunoglobulin-E syndrome presenting with widespread oral papillomas which were tested for human papilloma virus DNA and had shown to be at high/intermediate risk group for malignancy. She had elevated levels of IgE, recurrent sinopulmonary infections, atopic-like dermatitis, peripheral eosinophilia and defective neutrophil chemotaxis. Interferon alfa 2b therapy and chemoprophylaxis with sulfamethoxazole-trimethoprim was given. Although the papillomas partially improved with the treatment, sinopulmonary infections continue to occur.