Prokineticin receptor-1 induces neovascularization and epicardial-derived progenitor cell differentiation

Urayama, Kyoji; Guilini, Celia; Turkeri, Gulen; Takir, Selcuk; Kurose, Hitoshi; Messaddeq, Nadia; Dierich, Andree; Nebigil, Canan

doi:10.1161/atvbaha.108.162404

Prokineticin receptor-1 induces neovascularization and epicardial-derived progenitor cell differentiation

Urayama K., Guilini C., Turkeri G., Takir S., Kurose H., Messaddeq N., ...More

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, vol.28, no.5, pp.841-849, 2008 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 28 Issue: 5
Publication Date: 2008
Doi Number: 10.1161/atvbaha.108.162404
Journal Name: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.841-849
Istanbul University Affiliated: No

Abstract

Objective-Identification of novel factors that contribute to myocardial repair and collateral vessel growth hold promise for treatment of heart diseases. We have shown that transient prokineticin receptor-1 (PKR1) gene transfer protects the heart against myocardial infarction in a mouse model. Here, we investigated the role of excessive PKR1 signaling in heart.