Prokineticin receptor-1 induces neovascularization and epicardial-derived progenitor cell differentiation


Urayama K., Guilini C., Turkeri G., Takir S., Kurose H., Messaddeq N., ...More

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, vol.28, no.5, pp.841-849, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 5
  • Publication Date: 2008
  • Doi Number: 10.1161/atvbaha.108.162404
  • Title of Journal : ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
  • Page Numbers: pp.841-849

Abstract

Objective-Identification of novel factors that contribute to myocardial repair and collateral vessel growth hold promise for treatment of heart diseases. We have shown that transient prokineticin receptor-1 (PKR1) gene transfer protects the heart against myocardial infarction in a mouse model. Here, we investigated the role of excessive PKR1 signaling in heart.