Expression of heat shock proteins 27, 60 and 70 in oral carcinogenesis: An immunohistochemical study
TÜRK ONKOLOJİ DERGİSİ, vol.26, no.3, pp.115-120, 2011 (Scopus)
- Publication Type: Article / Article
- Volume: 26 Issue: 3
- Publication Date: 2011
- Journal Name: TÜRK ONKOLOJİ DERGİSİ
- Journal Indexes: Scopus
- Page Numbers: pp.115-120
- Istanbul University Affiliated: Yes
Abstract
Summary
OBJECTIVES
Heat shock proteins (HSPs) are a class of functionally related proteins, the expression of which is increased when cells are exposed to elevated temperatures or other stresses, including infection, irradiation, heavy metals, ethanol, and oxidants. The aim of this study was to investigate the significance of HSP60, HSP70 and HSP27 as prognostic factors in different stages of oral carcinogenesis by immunohistochemical analysis.
METHODS
Twenty specimens of oral squamous cell carcinoma (OSCC) of the oral cavity were immunostained for HSPs to expose differences in stainability among normal epithelium (n=20) and leukoplakia (n=20) as dysplasia.
RESULTS
Immunohistochemistry demonstrated that OSCC cells were positive for all of HSP60, HSP70 and HSP27. Leukoplakia cases were positive for HSP70 and HSP27, but stained with variability for HSP60. Normal epithelium expressed HSP60 and to a lesser extent HSP70, while HSP27 were hardly ever expressed. The HSP70 and HSP27 stainings in OSCC were significantly higher than in normal epithelium, and demonstrated almost the same staining character as with leukoplakia.
CONCLUSION
Our results demonstrated that HSP immunochemistry revealed changes in especially HSP70 and HSP27 expression during tumorigenesis of squamous epithelium of the oral cavity.