Akademik Veri Yönetim Sistemi
Journal of Drug Delivery Science and Technology, cilt.117, 2026 (SCI-Expanded, Scopus)
Intranasal drug delivery has emerged as an effective, non-invasive strategy for targeting both systemic circulation and the central nervous system (CNS), offering a means to bypass first-pass metabolism and the blood–brain barrier (BBB). This route can significantly improve drug bioavailability and therapeutic outcomes. Among the various nanomaterials investigated for intranasal applications, carbon dots (CDs) have attracted growing interest due to their ultra-small size, tunable surface functionalization, strong photoluminescence, high aqueous solubility, chemical stability, favorable biocompatibility, and minimal cytotoxicity. These features make CDs particularly well suited for both therapeutic delivery and theranostic applications. This review provides a comprehensive overview of recent advances in CD-based intranasal delivery systems, with emphasis on their ability to enhance transport across biological barriers, improve drug stability and targeting, and support real-time imaging. Key strategies in formulation design, surface functionalization, and preclinical performance are discussed, alongside critical limitations affecting clinical translation, including incomplete mechanistic understanding, safety evaluation gaps, and challenges related to reproducibility. Together, these insights provide a framework to guide the rational design of CD-enabled intranasal systems and to inform future efforts aimed at translating preclinical advances into clinically applicable nasal drug delivery technologies.