Pre-therapeutic dosimetry of normal organs and tissues of Lu-177-PSMA-617 prostate-specific membrane antigen (PSMA) inhibitor in patients with castration-resistant prostate cancer

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Kabasakal L., AbuQbeitah M., Aygun A., Yeyin N., Ocak M., Demirci E., ...Daha Fazla

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, cilt.42, sa.13, ss.1976-1983, 2015 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 42 Sayı: 13
• Basım Tarihi: 2015
• Doi Numarası: 10.1007/s00259-015-3125-3
• Dergi Adı: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.1976-1983
• Anahtar Kelimeler: Prostate cancer, Radionuclide treatment, Prostate specific membrane antigen, PSMA, Lu-177-PSMA, Castration resistant, Radiometabolic therapy, RECEPTOR RADIONUCLIDE THERAPY, SALIVARY-GLAND FUNCTION, BONE-MARROW DOSIMETRY, INDIVIDUALIZED DOSIMETRY, PRECLINICAL EVALUATION, RADIATION, LIGAND, RADIOTHERAPY, XEROSTOMIA, EXPRESSION
• İstanbul Üniversitesi Adresli: Evet

Özet

Purpose Lu-177-617-prostate-specific membrane antigen (PSMA) ligand seems to be a promising tracer for radionuclide therapy of progressive prostate cancer. However, there are no published data regarding the radiation dose given to the normal tissues. The aim of the present study was to estimate the pretreatment radiation doses in patients who will undergo radiometabolic therapy using a tracer amount of Lu-177-labeled PSMA ligand.