Investigations on enteric coated tenoxicam tablets

Levi M., CEVHER E., ŞAHİN N., ARAMAN A. O.

Acta Pharmaceutica Turcica, vol.42, no.2-3, pp.72-78, 2000 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 2-3
  • Publication Date: 2000
  • Journal Name: Acta Pharmaceutica Turcica
  • Journal Indexes: Scopus
  • Page Numbers: pp.72-78
  • Keywords: Aquateric, CAP, CAT, Enteric coating, Eudragit L-100, Film coating, Tenoxicam
  • Istanbul University Affiliated: Yes

Abstract

Tenoxicam, a tienotiazine derivative nonsteroid anti-inflammatory agent of oxicam class, is used in articular and extra-articular disturbances. One of the most important side effects of tenoxicam is its irritative effect on stomach mucosa like all other anti-inflammatory drugs. In order to overcome such problems, tenoxicam containing tablets were enteric coated with variours enteric film coating agents such as CAP, CAT, Aquateric, and Eudragit L-100 in this study. The release profiles of enteric-coated tenoxicam tablets were investigated in a buffered medium at different pH values. It was observed from the release profiles that pH affects the solubility of the drug substance and disitegration of the coating materials. The highest dissolution rate was obtained for the tablets coated with Aquateric.