ANALYSIS OF UPREGULATED-UNCHARACTERIZED GENES INFLUENCING LIFESPAN UNDER METFORMIN TREATMENT IN FISSION YEAST

Tarhan Ç., Çalıcı Z., Özden B.

3rd INTERNATIONAL CONGRESS ON CONTEMPORARY SCIENTIFIC RESEARCH held on August 7-8, 2023 / Adana, Türkiye, Adana, Türkiye, 7 - 08 Ağustos 2023, ss.54-55

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: Adana
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.54-55
  • İstanbul Üniversitesi Adresli: Evet

Özet

Aging is the sum of events that lead the organism to death as a result of structural and

functional changes, which are regulated by a genetic program and occur with the effect of

environmental factors. After it was understood that aging is a genetically regulated process,

which genes play a role and how these genes affect aging with environmental changes have

gained great importance. In addition, the detection of metabolic interventions and active

substances that delay or slow down aging paved the way for intervention in the aging process.

Metformin, which has been used as a primary drug in the treatment of type 2 diabetes for

many years, has also started to be investigated as an anti-aging drug because it affects nine

distinguishing features of aging. In this study, we focused on the changes in uncharacterized

genes in the RNA-seq analysis we conducted to investigate which genes resulted from the

change in expression of this life-prolonging effect in fission yeast, whose lifespan was

increased by approximately fifty percent under metformin treatment. In this study, we focused

on the changes in uncharacterized genes in the previous RNA-seq analysis we conducted to

investigate the expression of genes that increased the lifespan of the fission yeast by about

fifty percent under metformin treatment. Among uncharacterized genes that are predicted to

have different functions and whose expression varies at different rates, it was observed that

the expression of genes related to meiosis and genes responsible for recombination increased

as a result of metformin treatment. Among these genes, genes whose expression is strongly

increased may be important candidates for understanding the aging process. In addition, the

upregulation of genes related to meiosis suggests that metformin increased lifespan by

mimicking calorie restriction conditions even in the presence of glucose.