Flupirtine may stop the progressive course of subacute sclerosing panencephalitis

Tatli B., Ekici B., Ozmen M.

MEDICAL HYPOTHESES, cilt.75, sa.6, ss.576-577, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 75 Sayı: 6
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.mehy.2010.07.035
  • Dergi Adı: MEDICAL HYPOTHESES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.576-577
  • İstanbul Üniversitesi Adresli: Evet

Özet

Subacute sclerosing panencephalitis (SSPE) is a progressive devastating disease. Along with the slow measles virus infection, apoptotic cell death has shown to be one of the major mechanisms at the pathogenesis. Volume reduction in frontotemporal cortex has seen in patients at early stages of disease. At present, there is no effective treatment to completely cure SSPE. Oral isoprinosine and intrathecal or intraventricular alpha-interferon are anti viral therapies with limited success.