Role of simvastatin and ROR alpha activity in the macrophage apoptotic pathway

Coban N., Gulec Ç., Selcuk B. O., Erginel-Unaltuna N.

ANATOLIAN JOURNAL OF CARDIOLOGY, cilt.17, sa.5, ss.362-366, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 5
  • Basım Tarihi: 2017
  • Doi Numarası: 10.14744/anatoljcardiol.2016.7411
  • Dergi Adı: ANATOLIAN JOURNAL OF CARDIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.362-366
  • Anahtar Kelimeler: ROR alpha ligands, atherosclerosis, simvastatin, apoptosis, THP-1 macrophage, cell viability, INFLAMMATORY RESPONSE, ACTIVATION, ATHEROSCLEROSIS, EXPRESSION, CANCER, PLAQUE, POLARIZATION, PLASTICITY, MELATONIN, PARADIGM
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: Atherosclerosis is a chronic inflammatory condition and is one of the main causes of death worldwide. Macrophages play important roles in the formation of atherosclerotic plaques. Apoptosis is progressively observed while plaques develop, although the precise mechanisms and outcomes of apoptosis in atherosclerosis development and progression are still contradictory. This study was conducted to explore the effects of simvastatin and retinoic acid receptor-related orphan receptor alpha (ROR alpha) ligands on apoptosis in human acute monocytic leukemia (THP-1) macrophage cells.