IN VITRO ANTICANCER ACTIVITY AND CYTOTOXICITY OF SOME PAPAVER ALKALOIDS ON CANCER AND NORMAL CELL LINES

Demirgan R., Karagoz A., Pekmez M., Onay-Ucar E., Artun F. T., Gurer Ç., ...Daha Fazla

AFRICAN JOURNAL OF TRADITIONAL COMPLEMENTARY AND ALTERNATIVE MEDICINES, cilt.13, sa.3, ss.22-26, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.4314/ajtcam.v13i3.3
  • Dergi Adı: AFRICAN JOURNAL OF TRADITIONAL COMPLEMENTARY AND ALTERNATIVE MEDICINES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, Veterinary Science Database
  • Sayfa Sayıları: ss.22-26
  • Anahtar Kelimeler: Cytotoxicity, Anticancer activity, Papaver alkaloids, HeLa cell line, Vero cell line, MTT assay, ISOQUINOLINE ALKALOIDS, ANTIBACTERIAL ACTIVITY, BIOACTIVITY
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: The purpose of this study is to determine the effect of in vitro anticancer activity and cytotoxicity of 13 Papaver alkaloids (amurine, armepavine, berberine, isocorydine, isothebaine, macranthine, mecambrine, mecambridine, narkotine, orientalidine, oripavine, salutaridine and thebaine) against the human cervical cancer cell line (HeLa) compared to the normal African green monkey kidney epithelial cell line (Vero) using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.