IN VITRO ANTICANCER ACTIVITY AND CYTOTOXICITY OF SOME PAPAVER ALKALOIDS ON CANCER AND NORMAL CELL LINES

Demirgan R., Karagoz A., Pekmez M., Onay-Ucar E., Artun F. T., Gurer Ç., ...More

AFRICAN JOURNAL OF TRADITIONAL COMPLEMENTARY AND ALTERNATIVE MEDICINES, vol.13, no.3, pp.22-26, 2016 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 3
  • Publication Date: 2016
  • Doi Number: 10.4314/ajtcam.v13i3.3
  • Journal Name: AFRICAN JOURNAL OF TRADITIONAL COMPLEMENTARY AND ALTERNATIVE MEDICINES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, Veterinary Science Database
  • Page Numbers: pp.22-26
  • Keywords: Cytotoxicity, Anticancer activity, Papaver alkaloids, HeLa cell line, Vero cell line, MTT assay, ISOQUINOLINE ALKALOIDS, ANTIBACTERIAL ACTIVITY, BIOACTIVITY
  • Istanbul University Affiliated: Yes

Abstract

Background: The purpose of this study is to determine the effect of in vitro anticancer activity and cytotoxicity of 13 Papaver alkaloids (amurine, armepavine, berberine, isocorydine, isothebaine, macranthine, mecambrine, mecambridine, narkotine, orientalidine, oripavine, salutaridine and thebaine) against the human cervical cancer cell line (HeLa) compared to the normal African green monkey kidney epithelial cell line (Vero) using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.