Genotoxic potential of cyclosporin A in patients with renal transplantation
CELL BIOLOGY AND TOXICOLOGY, cilt.15, sa.1, ss.13-17, 1999 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 15 Sayı: 1
- Basım Tarihi: 1999
- Doi Numarası: 10.1023/a:1007594421458
- Dergi Adı: CELL BIOLOGY AND TOXICOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.13-17
- İstanbul Üniversitesi Adresli: Hayır
Özet
We analyzed the induction of sister chromatid exchange (SCE) by cyclosporin A (CsA) as a marker of genotoxic potential. In 30 patients undergoing renal transplantation, SCE induction was tested before the introduction of CsA and 3 months later. We found that SCE frequency increased significantly at the end of 3 months. To our knowledge, this is the first study demonstrating in viva induction of SCE by CsA in humans. We conclude that CsA has a genotoxic potential on human lymphocytes.