Genotoxic potential of cyclosporin A in patients with renal transplantation

Palanduz S., Sever M., Ozturk S., Tascioglu C., Karan M., Sonmez G., ...More

CELL BIOLOGY AND TOXICOLOGY, vol.15, no.1, pp.13-17, 1999 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 1
  • Publication Date: 1999
  • Doi Number: 10.1023/a:1007594421458
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.13-17
  • Istanbul University Affiliated: No


We analyzed the induction of sister chromatid exchange (SCE) by cyclosporin A (CsA) as a marker of genotoxic potential. In 30 patients undergoing renal transplantation, SCE induction was tested before the introduction of CsA and 3 months later. We found that SCE frequency increased significantly at the end of 3 months. To our knowledge, this is the first study demonstrating in viva induction of SCE by CsA in humans. We conclude that CsA has a genotoxic potential on human lymphocytes.