Genotoxic potential of cyclosporin A in patients with renal transplantation


Palanduz S. , Sever M., Ozturk S. , Tascioglu C., Karan M., Sonmez G., ...Daha Fazla

CELL BIOLOGY AND TOXICOLOGY, cilt.15, ss.13-17, 1999 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 15 Konu: 1
  • Basım Tarihi: 1999
  • Doi Numarası: 10.1023/a:1007594421458
  • Dergi Adı: CELL BIOLOGY AND TOXICOLOGY
  • Sayfa Sayıları: ss.13-17

Özet

We analyzed the induction of sister chromatid exchange (SCE) by cyclosporin A (CsA) as a marker of genotoxic potential. In 30 patients undergoing renal transplantation, SCE induction was tested before the introduction of CsA and 3 months later. We found that SCE frequency increased significantly at the end of 3 months. To our knowledge, this is the first study demonstrating in viva induction of SCE by CsA in humans. We conclude that CsA has a genotoxic potential on human lymphocytes.