A rapid liquid chromatography/tandem mass spectrometry method for simultaneous determination of levodopa, carbidopa, entacapone and their six related compounds in film-coated tablets

Burmaoglu R. E., Sağlık Aslan S.

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, vol.34, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34
  • Publication Date: 2020
  • Doi Number: 10.1002/rcm.8782
  • Journal Name: RAPID COMMUNICATIONS IN MASS SPECTROMETRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Analytical Abstracts, BIOSIS, Chimica, Communication Abstracts, EMBASE, MEDLINE, Metadex, Civil Engineering Abstracts
  • Istanbul University Affiliated: Yes

Abstract

Rationale A liquid chromatography/tandem mass spectrometry (LC/MS/MS) method has been developed and validated to determine levodopa, carbidopa, entacapone, and corresponding six related substances - levodopa impurity B, levodopa impurity C, methyldopa, methylcarbidopa, entacapone impurity C, and entacapone impurity A - in film-coated tablets for the first time.