A rapid liquid chromatography/tandem mass spectrometry method for simultaneous determination of levodopa, carbidopa, entacapone and their six related compounds in film-coated tablets


Burmaoglu R. E. , SAĞLIK ASLAN S.

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, cilt.34, 2020 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 34 Konu: 12
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1002/rcm.8782
  • Dergi Adı: RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Özet

Rationale A liquid chromatography/tandem mass spectrometry (LC/MS/MS) method has been developed and validated to determine levodopa, carbidopa, entacapone, and corresponding six related substances - levodopa impurity B, levodopa impurity C, methyldopa, methylcarbidopa, entacapone impurity C, and entacapone impurity A - in film-coated tablets for the first time.