Bingul I., Kucukgergin C., Aydin A. F., Ekici I. D., Abbasoglu S. D., Uysal M.
JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI, vol.84, no.3, pp.360-368, 2021 (ESCI)
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Publication Type:
Article / Article
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Volume:
84
Issue:
3
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Publication Date:
2021
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Doi Number:
10.26650/iuitfd.2021.849531
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Journal Name:
JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI
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Journal Indexes:
Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
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Page Numbers:
pp.360-368
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Keywords:
Vitamin D deficiency, high fructose diet, nonalcoholic liver disease, glycooxidative stress, antioxidant, inflammation, GLYCATION END-PRODUCTS, OXIDATIVE STRESS, INSULIN-RESISTANCE, INFLAMMATION, FIBROSIS, MODELS
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Istanbul University Affiliated:
Yes
Abstract
Objective: Vitamin D has antioxidant, anti-inflammatory and antiglycation activities, and hepatoprotective potential. There is a relationship between vitamin D deficiency (VDD) and the severity
of liver disorders. VDD has been proposed to contribute to the progression of nonalcoholic fatty liver disease (NAFLD). However, experimental results are not clear. Therefore, in this study,
the effects of a VDD diet on high fructose (HFr) drinking-induced NAFLD was evaluated.
Material and Method: Male Wistar rats were divided into four groups as control, HFr, VDD+HFr, and VDD. Control and HFr groups were fed a control diet, and other groups with a VDD-diet
for 12 weeks. HFr (30%; w/v; in drinking water) was given in the last 8 weeks. Insulin resistance (IR), serum lipids, hepatic triglyceride, lipid peroxide, protein carbonyl, advanced glycation end
products (AGEs) and inflammation (TNF-α and myeloperoxidase) parameters, and histopathological changes were investigated.
Results: Increases in serum transaminases, hypertriglyceridemia, and IR were observed in HFr and VDD+HFr groups. Increased liver triglyceride, lipid and protein oxidation products, protein
glycation and inflammation markers as well as microvesicular hepatic steatosis and hepatocyte ballooning were observed in both groups. Although IR and hepatic inflammation markers
were higher in the VDD+HFr group, serum transaminases, hepatic triglyceride, lipid and protein oxidation products, and glycation indicators in the liver did not alter between the two groups.
However, Nrf2 mRNA expression and superoxide dismutase and glutathione peroxidase mRNA expression and activities were significantly higher in the VDD+HFr group.
Conclusion: Our results show that VDD did not augmented HFr-induced hepatotoxicity and glycooxidative stress in the liver of rats.