Altered Metabolic Integrity of Corpus Callosum Among Individuals at Ultra High Risk of Schizophrenia and First-Episode Patients
BIOLOGICAL PSYCHIATRY, vol.64, no.9, pp.750-757, 2008 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 64 Issue: 9
- Publication Date: 2008
- Doi Number: 10.1016/j.biopsych.2008.04.007
- Journal Name: BIOLOGICAL PSYCHIATRY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.750-757
- Istanbul University Affiliated: Yes
Abstract
Background: The disconnectivity hypothesis as part of the neurodevelopmental model of schizophrenia states that an abnormality in brain development causing impaired corticocortical or interhemispheric connectivity leads to cognitive deficits and symptoms of the illness. Previous studies showed the altered morphology of corpus callosum in patients with schizophrenia. We investigated the metabolic integrity of corpus callosum of individuals at ultra high risk (UHR) of developing schizophrenia and first-episode patients.