Altered Metabolic Integrity of Corpus Callosum Among Individuals at Ultra High Risk of Schizophrenia and First-Episode Patients

Aydin K. , Ucok A. , GULER J.

BIOLOGICAL PSYCHIATRY, vol.64, no.9, pp.750-757, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 64 Issue: 9
  • Publication Date: 2008
  • Doi Number: 10.1016/j.biopsych.2008.04.007
  • Title of Journal : BIOLOGICAL PSYCHIATRY
  • Page Numbers: pp.750-757


Background: The disconnectivity hypothesis as part of the neurodevelopmental model of schizophrenia states that an abnormality in brain development causing impaired corticocortical or interhemispheric connectivity leads to cognitive deficits and symptoms of the illness. Previous studies showed the altered morphology of corpus callosum in patients with schizophrenia. We investigated the metabolic integrity of corpus callosum of individuals at ultra high risk (UHR) of developing schizophrenia and first-episode patients.