Pretreatment electroencephalographic features in patients with childhood absence epilepsy

Ozcelik E. U., Cokar O., Demirbilek V.

NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY, vol.52, no.4, pp.280-289, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 52 Issue: 4
  • Publication Date: 2022
  • Doi Number: 10.1016/j.neucli.2022.07.003
  • Journal Name: NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, BIOSIS, EMBASE, MEDLINE
  • Page Numbers: pp.280-289
  • Keywords: Absence seizures, Childhood, Drug -naive, EEG, Epilepsy, Pretreatment, IDIOPATHIC GENERALIZED EPILEPSY, SPIKE-WAVE DISCHARGES, LONG-TERM PROGNOSIS, INTERICTAL SPIKING, SEIZURES, EEG, SLEEP, CHILDREN, PATHOPHYSIOLOGY, CLASSIFICATION
  • Istanbul University Affiliated: Yes

Abstract

Objective: To analyze the ictal and interictal electroencephalographic (EEG) features in newly diagnosed childhood absence epilepsy (CAE) and determine the association between seizure onset topography, interictal focal spike-wave discharges (FSWDs) and accompanying clinical fea-tures of absence seizures.Methods: The authors searched the EEG database for a definite diagnosis of CAE according to ILAE 2017 criteria. Video-EEGs of untreated pediatric patients during sleep and wakefulness were evaluated retrospectively.Results: The study included 47 patients (25 males, 22 females). Interictal FSWDs were observed in 49% of patients with CAE during wakefulness and in 85.1% during sleep (p = 0.001). Interictal FSWDs were most frequently observed in the frontal regions (awake: 34%; asleep: 74.5%), followed by the posterior temporoparietooccipital region (awake: 21.2%; asleep: 36.1%), and the centrotemporal region (awake: 6.4%; asleep: 8.5%). Eleven patients (23.4%) had polyspikes during sleep. Both bilateral symmetric and asymmetric sei-zure onset were noted in 32%, whereas focal seizure onset was observed in 14.9% of the patients. Absence seizures with and without motor components were seen in 72.3% and 61.7% of patients, respectively, and in 33% of patients both occurred. There were no associ-ations between the existence of interictal FSWDs, focal/asymmetric seizure onset, and absence seizures with and/or without motor components.