Attitudes of caregivers of children labeled with drug allergy after delabeling by provocation tests
Pediatric Allergy and Immunology, cilt.37, sa.7, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 37 Sayı: 7
- Basım Tarihi: 2026
- Doi Numarası: 10.1111/pai.70435
- Dergi Adı: Pediatric Allergy and Immunology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Academic Search Ultimate (EBSCO), Natural Science Collection (ProQuest), Biological Science Database (ProQuest), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest)
- Anahtar Kelimeler: caregiver attitudes, delabeling, drug allergy, drug hypersensitivity reaction, drug provocation test, NSAID allergy, pediatric allergy, penicillin allergy
- İstanbul Üniversitesi Adresli: Evet
Özet
Background: Mislabeling children as drug-allergic leads to suboptimal, costly, and potentially harmful treatments. Although drug provocation tests (DPTs) are the gold standard for excluding drug hypersensitivity, the impact of these interventions on caregivers' willingness to reuse delabeled drugs remains elusive. We evaluated DPT outcomes and post-DPT drug use and caregiver attitudes in pediatric patients. Methods: We analyzed children who underwent DPTs for suspected drug allergy at a tertiary pediatric allergy center between January 2019 and June 2023. Demographic and clinical data were reviewed, and caregivers were contacted ≥6 months after DPT to assess subsequent drug use and concerns. Results: A total of 254 DPTs were performed in 198 children (55.1% male; median age: 58 months). Drug allergy was confirmed in 25.3% of patients (50/198), corresponding to 22.0% of tests (56/254). Among 162 negative DPTs with follow-up, the suspected drug was reused in 56.8% of cases; 92.4% were tolerated while 7.6% resulted in mild reactions. Multivariable logistic regression identified predictors of drug reuse: paracetamol (aOR: 7.40; 95% CI: 1.73–31.63; p =.007), concomitant allergic disease (aOR: 2.51; 95% CI: 1.12–5.64; p =.026), self-referral (aOR: 3.81; 95% CI: 1.12–12.95; p =.032), and younger age (aOR per month: 0.99; 95% CI: 0.98–1.00; p =.017). Anaphylaxis at index reaction was associated with reduced reuse likelihood (aOR: 0.21; 95% CI: 0.06–0.76; p =.018). Conclusion: Despite negative DPT results, almost half of caregivers did not reuse the suspected drug, mostly due to fear or miscommunication. These findings highlight the importance of post-DPT education and structured follow-up to optimize delabeling outcomes. (Figure presented.).